Vascular Research Center
Accueil » Plan du site
Plan du site
Le labo
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Thématiques de recherche
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Physiopathologie de l’endothélium
- Rôle de CD146 dans l’inflammation et l’angiogénèse
- Mécanismes de lésion et de régénération endothéliale
- Dysfonction endothéliale et insuffisance rénale chronique
- Endothélium, thrombose et cancer
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Physiopathologie de l’endothélium
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Le personnel
- AHU-CCA
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Chercheurs et enseignants-chercheurs
- Foucault-Bertaud Alexandrine
- Granel Brigitte
- Rossi Pascal
- Bonello Laurent
- Vacher-Coponat Henri
- Sielezneff Igor
- Sabatier Florence
- Paganelli Franck
- Charpiot Philippe
- Brunet Philippe
- Panicot-Dubois Laurence
- Jourde-Chiche Noémie
- Paul Pascale
- Dussol Bertrand
- Hache Guillaume
- Guillet Benjamin
- Pisano Pascale
- Lacroix Romaric
- Leroyer Aurélie
- Frere Corinne
- Burtey Stéphane
- Blot-Chabaud Marcel
- Kaplanski Gilles
- Cerini Claire
- Bardin Nathalie
- Poitevin Stéphane
- Tellier Edwige
- Dubois Christophe
- Dignat-George Françoise
- Ingénieurs et techniciens
- Doctorants et post-doctorants
- Personnel administratif
Les plates-formes
Formations
Publications
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Communications internationales
- The origin and concentration of circulating microparticles differ according to cancer type and evolution : A prospective single-center study.
- Platelet and not erythrocyte microparticles are procoagulant in transfused thalassaemia major patients
- Standardized counting of circulating platelet microparticles using currently available flow cytometers and scatter-based triggering : Forward or side scatter ?
- CD146 mediates VEGF-induced melanoma cell extravasation through FAK activation
- Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo
- CD146 mediates VEGF-induced melanoma cell extravasation through FAK activation
- Prelamin A accumulation in endothelial cells induces premature senescence and functional impairment
- The Cardiovascular Effect of the Uremic Solute Indole-3 Acetic Acid
- P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice
- Circulating endothelial cells and progenitors as prognosis factors during auto-immune thrombotic thrombocytopenic purpura : Results of a prospective multicenter french study.
- Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity.
- Neutrophils recruit and activate human endothelial colony-forming cells at the site of vessel injury via P-selectin glycoprotein ligand-1 and L-selectin
- Reply : Adenosine plasma concentration increase by ticagrelor in patients with acute coronary syndrome : no cause for fear in clinical practice
- Involvement of platelet-derived microparticles in tumor progression and thrombosis
- Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo.
- Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression.
- Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome.
- Forearm ischemia decreases endothelial colony-forming cell angiogenic potential.
- Altered angiogenesis in low birth weight individuals : a role for anti-angiogenic circulating factors
- Involvement of neutrophils in thrombus formation in living mice
- Plasmatic levels of leukocyte-derived microparticles predict unstable plaque in asymptomatic patients with high-grade carotid stenosis
- Soluble melanoma cell adhesionmolecule (sMCAM/sCD146) promotes angiogenic effects on endothelial progenitor cells through angiomotin
- Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway
- Identification of soluble CD146 as a regulator of trophoblast migration : potential role in placental vascular development
- A&R special issue : Disease mechanisms in rheumatology. Tools and pathways
- Microparticles : new protagonists in pericellular and intravascular proteolysis
- The Involvement of CD146 and Its Novel Ligand Galectin-1 in Apoptotic Regulation of Endothelial cells
- Thrombocytopenia is not mandatory to diagnose haemolytic and uremic syndrome
- Antimalarial ototoxicity : an underdiagnosed complication ? A study of spontaneous reports to the French Pharmacovigilance Network
- Priming of late endothelial progenitor cells with erythropoietin before transplantation requires the CD131 receptor subunit and enhances their angiogenic potential
- Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation
- Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein
- Impact of pre-analytical parameters on the measurement of circulating microparticles : towards standardization of protocol
- Leukocyte- and endothelialSderived microparticles:a circulating source of fibrinolysis
- Premature birth is associated with not fully differentiated contractile smooth muscle cells in human umbilical artery.
- The contribution of antiphosphatidylethanolamine antibodies in the diagnosis of the antiphospholipid syndrome
- Seasonal variations of systemic lupus erythematosus flares in southern France
- High-Sensitivity Flow Cytometry Provides Access to Standardized Measurement of Small-Size Microparticles
- Comparative safety and efficiency of five percutaneous kidney biopsy approaches of native kidneys : a multicenter study
- Association between anti-C1q antibodies and glomerular tuft necrosis in lupus nephritis
- Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles
- Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1alpha
- High Resolution Melt analysis for mutation screening in PKD1 and PKD2
- Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome : relationship with oxidative stress.
- Fractalkine expression induces endothelial progenitor cell lysis by natural killer cells
- More on : calibration for the measurement of microparticles : value of calibrated polystyrene beads for flow cytometry-based sizing of biological microparticles
- A switch towards angiostatic gene expression impairs the angiogenic properties of endothelial progenitor cells in low birth weight pre-term infants
- Association of PKD2 (polycystin 2) mutations with left-right laterality defects
- Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors.
- Does uremia cause vascular dysfunction ?
- Vascular incompetence in dialysis patients—protein-bound uremic toxins and endothelial dysfunction
- Microparticles from human atherosclerotic plaques promote endothelial ICAM-1-dependent monocyte adhesion and transendothelial migration
- Overcoming limitations of measurement of microparticles by flow cytometry
- Guanidino compounds as cause of cardiovascular damage in chronic kidney disease : an in vitro evaluation
- Level of ADP receptor P2Y12 blockade during percutaneous coronary intervention predicts the extent of endothelial injury, assessed by CEC measurement
- Natural resistance to HIV infection : lessons learned from HIV‐exposed uninfected individuals
- Tissue factor up-regulation in proinflammatory conditions confers thrombin generation capacity to endothelial colony-forming cells without influencing non-coagulant properties in vitro
- Endothelial-derived microparticles : biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis
- CD146 short isoform increases the proangiogenic potential of endothelial progenitor cells in vitro and in vivo
- Erythropoietin and cerebral protection after acute injuries : a double-edged sword ?
- Determination of uremic solutes in biological fluids of chronic kidney disease patients by HPLC assay
- Soluble CD146 displays angiogenic properties and promotes neovascularization in experimental hind-limb ischemia
- Fibrinolytic cross-talk : a new mechanism for plasmin formation
- Myocardial infarction is a complication of factor H-associated atypical HUS
- Increased vitreous shedding of microparticles in proliferative diabetic retinopathy stimulates endothelial proliferation
- CD146 and its soluble form regulate monocyte transendothelial migration
- Cancer cell-derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo
- Standardization of platelet-derived microparticle counting using calibrated beads and a Cytomics FC500 routine flow cytometer : a first step towards multicenter studies ?
- Generation of human inflammation-resistant endothelial progenitor cells by A20 gene transfer
- Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study
- Levels of circulating endothelial progenitor cells are related to uremic toxins and vascular injury in hemodialysis patients
- Protein-bound toxins—update 2009
- IL-10 inhibits apoptosis and microvesiculation of human monocytes
- Microparticles from ischemic muscle promote postnatal vasculogenesis
- Sevoflurane preconditioning against focal cerebral ischemia : Sustain inhibition of apoptosis in the face of transient improvement of neurological outcome
- TRAIL/Apo2L mediates the release of procoagulant endothelial microparticles induced by thrombin in vitro : a potential mechanism linking inflammation and coagulation
- Chocolate intake associated with failed labeling of (99m)Tc red blood cells
- Kidney transplantation decreases the level and procoagulant activity of circulating microparticles
- Impact of immunosuppressive treatment on endothelial biomarkers after kidney transplantation
- Impact of immunosuppressive treatment on endothelial biomarkers after kidney transplantation
- CD40Ligand+ microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis : A potential mechanism for intra-plaque neovascularization
- Mouse CD146/MCAM is a marker of natural killer cell maturation
- Type I collagen induces tissue factor expression and matrix metalloproteinase 9 production in human primary monocytes through a redox-sensitive pathway
- Centrosome overduplication and mitotic instability in PKD2 transgenic lines
- Role of microparticles in atherothrombosis
- Overexpression of PKD2 in the mouse is associated with renal tubulopathy
- Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome
- HDLs activate ADAM17-dependent shedding
- Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans
- Activation of plasminogen into plasmin at the surface of endothelial microparticles : a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro
- Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1
- ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome
- Restoration of soluble CD146 in patients with Crohn’s disease treated with the TNF-alpha antagonist infliximab
- Soluble MHC Class I chain-related molecule serum levels are predictive markers of implantation failure and successful term pregnancies following IVF
- The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells
- Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals
- Activation of plasminogen into plasmin at the surface of endothelial microparticles : A mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro
- Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway
- Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model
- Monocyte IL-10 produced in response to lipopolysaccharide modulates thrombin generation by inhibiting tissue factor expression and release of active tissue factor-bound microparticles
- Cellular origin and thrombogenic activity of microparticles isolated from human atherosclerotic plaques
- The shedding activity of ADAM17 is sequestered in lipid rafts
- Thrombin-induced endothelial microparticle generation : identification of a novel pathway involving ROCK-II activation by caspase-2
- Sevoflurane protects rat mixed cerebrocortical neuronal-glial cell cultures against transient oxygen-glucose deprivation – Involvement of glutamate uptake and reactive oxygen species
- Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting
- Tacrolimus/mycophenolate mofetil improved natural killer lymphocyte reconstitution one year after kidney transplant by reference to cyclosporine/azathioprine
- FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity.
- Glycoprotein VI dependent and -independent pathways of thrombus formation in vivo
- Fine mapping of quantitative trait nucleotides underlying thrombin-activatable fibrinolysis inhibitor antigen levels by a transethnic study
- Elevation of circulating endothelial microparticles in patients with chronic renal failure
- Increased expression of CD146, a new marker of the endothelial junction in active inflammatory bowel disease
- Presence of endothelial progenitor cells, distinct from mature endothelial cells, within human CD146+ blood cells
- Technologist radiation exposure in routine 18FDG PET clinical practice
- Circulating endothelial microparticles are associated with vascular dysfunction in patients with end stage renal failure
- Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome
- PTP-1B is an essential positive regulator of platelet integrin signaling
- Cloning and expression of the amphibian homologue of the human PKD1 gene
- Quantification of thrombin activatable fibrinolysis inhibitor (TAFI) gene polymorphism effects on plasma levels of TAFI measured with assays insensitive to isoform-dependent artefact
- Vascular cell adhesion molecule-1 (VCAM-1) plays a central role in the pathogenesis of severe forms of vasculitis due to hepatitis C-associated mixed cryoglobulinemia
- Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome
- The first assessment of soluble CD146 in women with unexplained pregnancy loss. A new insight ?
- Circulating endothelial cell count as a diagnostic marker for non-ST-elevation acute coronary syndromes
- P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro
- The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair
- Neuroprotective effects of propofol in a model of ischemic cortical cell cultures – Insight on the role of glutamate
- Soluble CD146, a novel endothelial marker, is increased in physiopathological settings linked to endothelial junctional alteration
- Interleukin-6 : a regulator of the transition from neutrophilic to monocytic inflammation
- Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity
- P-cresol, a uremic toxin, decreases endothelial cell response to inflammatory cytokines
- Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor-dependent procoagulant activity
- Mutation screening of the PKD1 transcript by RT-PCR
- The IL-6-soluble IL-6R-alpha loop of endothelial activation as an intermediate between acute and chronic inflammation. An experimental model involving thrombin
- Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion
- The p38 mitogen activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment
- Tumor-specific up-regulation of the nonclassical class I HLA-G antigen expression in renal carcinoma
- Outside-in signaling pathway linked to CD146 engagement in human endothelial cells
- Increased soluble vascular cell adhesion molecule-1 (sCD106) concentrations in patients with the primary or systemic lupus erythematosus-related antiphospholipid syndrome. Correlations with the severity of thrombosis
- Pronounced effect of caprylocaproyl macrogolglycerides on nasal absorption of IS-159, a peptide serotonin 1B/1D receptor agonist
- Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells
- In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
- Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule-1 (ICAM-1, CD54) and vascular cell adhesion molecule-1 (VCAM-1, CD106)
- IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii is via a cell-associated IL-1alpha dependent pathway
- Brevets
